abstract：:We have tested the hypothesis that the inhibition by hydroxyurea of repair patch ligation and chromatin rearrangement during u.v.-induced DNA excision repair results from a reduction in cellular deoxyribonucleotide concentrations and not from a direct effect of hydroxyurea on the repair process. Using permeable human ...

journal_title：Carcinogenesis

authors： Hunting DJ,Dresler SL

更新日期：1985-10-01 00:00:00

abstract：:Sodium arsenite and sodium arsenate were observed to induce morphological transformation of Syrian hamster embryo cells in a dose-dependent manner. A linear dose-dependence with a slope of approximately 1 was observed with both compounds when the data were plotted on a log-log graph. The trivalent sodium arsenite was ...

journal_title：Carcinogenesis

authors： Lee TC,Oshimura M,Barrett JC

更新日期：1985-10-01 00:00:00

abstract：:Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide o...

journal_title：Carcinogenesis

authors： La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann D

更新日期：1985-10-01 00:00:00

abstract：:The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats. We have investigated whether the NAF-induced peroxisome proliferation in hepatocytes interferes with NDMA's metabolism and interaction with DNA. Adult male...

journal_title：Carcinogenesis

authors： Wiestler OD,Schmerold I,Fringes B,Volk B,Kleihues P

更新日期：1985-09-01 00:00:00

abstract：:Two new mouse epidermal cell lines have been isolated and characterized as target cells for three chemical carcinogens. The ability to grow these cells at low density (approximately 5 clonogenic cells/cm2) has permitted more precise quantitation of chemical carcinogen-induced changes in epidermal differentiation. The ...

journal_title：Carcinogenesis

authors： Kulesz-Martin M,Yoshida MA,Prestine L,Yuspa SH,Bertram JS

更新日期：1985-09-01 00:00:00

abstract：:Monoclonal or affinity-purified antibodies specific to Novikoff hepatoma cytokeratin p39 were employed to study the origin and fate of p39-containing cell types during hepatocarcinogenesis induced with N,N-dimethyl-p(m-tolylazo)aniline. Frozen sections were obtained from the livers of animals autopsied temporally duri...

journal_title：Carcinogenesis

authors： Schmidt WN,Page DL,McKusick K,Hnilica LS

更新日期：1985-08-01 00:00:00

abstract：:Metabolites of 15,16-dihydrocyclopenta[a]phenanthren-17-one and its 1- and 12-methyl homologues (all non-carcinogens) along with those from the 11-methyl and 11,12-dimethyl-17-ketones (carcinogens), produced in vitro by hepatic microsomes from methylcholanthrene induced rats, were separated by reverse phase h.p.l.c. I...

journal_title：Carcinogenesis

authors： Coombs MM,Russell JC,Jones JR,Ribeiro O

更新日期：1985-08-01 00:00:00

abstract：:U.v. damage to the DNA of HeLa cells induces the polymerisation of ADP-ribose, but only if repair synthesis is inhibited so that incomplete repair sites (i.e., DNA breaks) accumulate to abnormally high levels. 3-Aminobenzamide greatly reduces the ADP-ribose polymerisation response. However, 3-aminobenzamide does not r...

journal_title：Carcinogenesis

authors： Collins A

更新日期：1985-07-01 00:00:00

abstract：:3,3-[3H]Dimethyl-1-phenyltriazene, 1-(4-chlorophenyl)-3,3-[3H]dimethyltriazene and 3,3-[3H]dimethyl-1-(2,4,6-trichlorophenyl)-triazene methylate initiator tRNA in vitro only after pre-incubation with microsomal enzymes and NADPH. The finding confirms that procarcinogenic dialkyl aryltriazenes must be enzymatically con...

journal_title：Carcinogenesis

authors： Hradec J,Kolar GF

更新日期：1985-07-01 00:00:00

abstract：:The lymphocyte response to u.v. radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The u.v.-induced DNA synthesis was determined as the increase in incorporation of [3H]thymidine in irradiated cells compared with nonirradiated cells after incubation f...

journal_title：Carcinogenesis

authors： Munch-Petersen B,Frentz G,Squire B,Wallevik K,Horn CC,Reymann F,Faber M

更新日期：1985-06-01 00:00:00

abstract：:Thymidine kinase (TK), the enzyme in the pyrimidine salvage pathway, and its isozymes were examined in 15 specimens of normal mucosa, 14 polyps and 14 carcinomas in human colon. The average TK activities in colon polyps and carcinomas were about 1.6 and 2.9 times that in normal colon mucosa, respectively. The colon TK...

journal_title：Carcinogenesis

authors： Sakamoto S,Sagara T,Iwama T,Kawasaki T,Okamoto R

更新日期：1985-06-01 00:00:00

abstract：:Orotic acid, a precursor of pyrimidine nucleotide biosynthesis and a promoter for liver carcinogenesis, when fed at 1% level in a diet for 5 weeks resulted in liver DNA damage. The damage can be monitored as alkali-labile lesions using alkaline sucrose gradients as well as alkaline elution technique. Furthermore, the ...

journal_title：Carcinogenesis

authors： Rao PM,Rajalakshmi S,Alam A,Sarma DS,Pala M,Parodi S

更新日期：1985-05-01 00:00:00

abstract：:Rat hepatocytes maintained for up to 6 days in primary culture were used to test a variety of xenobiotics and steroids for effects on the activity of gamma-glutamyltranspeptidase (GGT) in normal cells. In control cultures GGT activity was low and increased slowly with time. When added to cultures for 5 days, a variety...

journal_title：Carcinogenesis

authors： Edwards AM,Lucas CM

更新日期：1985-05-01 00:00:00

abstract：:The rates of formation and disappearance of benzo[a]pyrene (B[a]P) DNA-adducts were analyzed in the epidermis of SENCAR mice over a 21-day time course. Mice were treated topically with 200 nmol/mouse of [3H]B[a]P at various times prior to sacrifice. The formation and disappearance of total adducts as well as individua...

journal_title：Carcinogenesis

authors： DiGiovanni J,Decina PC,Prichett WP,Fisher EP,Aalfs KK

更新日期：1985-05-01 00:00:00

abstract：:Dietary-related indoles, isothiocyanates, and the allyl isothiocyanate glucosinolate, sinigrin, were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h before sacrifice (acute protocol) and the effects of these pretreatments on the alpha-hydroxylation of two carcinogenic nitrosamines...

journal_title：Carcinogenesis

authors： Chung FL,Wang MY,Hecht SS

更新日期：1985-04-01 00:00:00

abstract：:The ability to repair damaged DNA was determined in different cell populations of rabbit lung cells isolated by centrifugal elutriation. DNA excision repair, measured as unscheduled DNA synthesis, was examined in in vitro confluent primary cultures. A dose dependent level of DNA excision repair was observed in alveola...

journal_title：Carcinogenesis

authors： Deilhaug T,Myrnes B,Aune T,Krokan H,Haugen A

更新日期：1985-04-01 00:00:00

abstract：:Nitrosamine-induced hepatocarcinogenesis has been used to investigate the regulation and expression of different drug-metabolizing enzymes in preneoplastic and neoplastic lesions in the female Wistar rat. The enzymes investigated were two phenobarbital-inducible cytochrome P-450 (cyt. P-450) isoenzymes (PB1 and PB2, m...

journal_title：Carcinogenesis

authors： Buchmann A,Kuhlmann W,Schwarz M,Kunz W,Wolf CR,Moll E,Friedberg T,Oesch F

更新日期：1985-04-01 00:00:00

abstract：:Transforming growth factors alpha and beta (TGF-alpha and TGF-beta) isolated from normal mouse kidney induced gross morphological changes in rat urothelial cells maintained in organ culture. These morphological effects are similar to those observed after long-term treatment of rat bladder organ cultures with the carci...

journal_title：Carcinogenesis

authors： Knowles MA,Hicks RM,Dave H,Harvey AE,Roberts AB,Sporn MB

更新日期：1985-04-01 00:00:00

abstract：:Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. DHEA has previo...

journal_title：Carcinogenesis

authors： Whitcomb JM,Schwartz AG

更新日期：1985-03-01 00:00:00

abstract：:The fluorescent 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue dansyl-TPA allowed the distribution of fluorescent molecules to be visualized in living mouse fibroblasts. The entry of dansyl-TPA into cells occurred within millisecond time scale and was found largely energy independent. Dansyl-TPA was shown to stai...

journal_title：Carcinogenesis

authors： Tran PL,Deugnier MA

更新日期：1985-03-01 00:00:00

abstract：:Since the results of an earlier study indicating no effect of dietary fat on dimethylhydrazine (DMH)-induced colon cancer in rats differed from those of other investigators, the present study was initiated to determine if the modulating effect of fat intake on colon tumorigenesis was dependent on the route of DMH admi...

journal_title：Carcinogenesis

authors： Locniskar M,Nauss KM,Kaufmann P,Newberne PM

更新日期：1985-03-01 00:00:00

abstract：:Syrian hamster embryo cells were treated with crocidolite asbestos at a dose (1 microgram/cm2) which was shown in previous studies to induce cell transformation and aneuploidy in these cells. Treatment of cells with asbestos induced a greater than 20-fold increase in the incidence of cells in anaphase with abnormaliti...

journal_title：Carcinogenesis

authors： Hesterberg TW,Barrett JC

更新日期：1985-03-01 00:00:00

abstract：:The arylamine carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMABP) has been proposed to be metabolically activated to DNA-binding derivatives through the formation of an N-hydroxy intermediate. In this study, the subsequent activation of N-hydroxy-DMABP through acid catalysis or enzymatic esterification was examined. [Rin...

journal_title：Carcinogenesis

authors： Flammang TJ,Westra JG,Kadlubar FF,Beland FA

更新日期：1985-02-01 00:00:00

abstract：:Eight different forms of cytochrome P-450 have been isolated from the liver microsomes of male Sprague-Dawley rats and compared with previously characterized forms on the basis of chromatographic behavior, absorption maximum of the carbon monooxide complex, apparent molecular weight upon SDS-disc gel electrophoresis, ...

journal_title：Carcinogenesis

authors： Aström A,DePierre JW

更新日期：1985-01-01 00:00:00

abstract：:Administration of methylglyoxal at doses of 300-600 mg/kg body weight by gastric tube to male F344 rats induced 100-fold increase in ornithine decarboxylase activity (formation of 682 pmol CO2/30 min/mg protein) within 7 h, 26-fold increase in DNA synthesis (incorporation of 17 800 d.p.m. of [3H]thymidine/microgram DN...

journal_title：Carcinogenesis

authors： Furihata C,Sato Y,Matsushima T,Tatematsu M

更新日期：1985-01-01 00:00:00

abstract：:A reduction in the ratio of tetraploid to diploid liver nuclei has been investigated as an early indicator of hepatocarcinogenesis in the rat using the liver carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'M). In a dose ranging study 3'M was administered by gavage to rats at 5, 12.5 and 25 mg/kg for up to 10 weeks a...

journal_title：Carcinogenesis

authors： Styles J,Elliott BM,Lefevre PA,Robinson M,Pritchard N,Hart D,Ashby J

更新日期：1985-01-01 00:00:00

abstract：:The age-dependence of the induction of pre-neoplastic enzyme-altered hepatic foci was investigated. Rats were exposed (8 h/day, 7 days/week) to 2000 p.p.m. vinyl chloride (VC) either 'transplacentally' (exposure of pregnant females), or immediately after birth for different time intervals (5, 11, 17, 47, 83 days) or f...

journal_title：Carcinogenesis

authors： Laib RJ,Klein KP,Bolt HM

更新日期：1985-01-01 00:00:00

abstract：:The resistant hepatocyte model was used to study expression of tumor-associated aldehyde dehydrogenase (ALDH) activity during the course of rat hepatocarcinogenesis. The hepatic ALDH phenotype was determined at intervals over 280 days by histochemical analysis, total ALDH activity assays and gel electrophoresis, using...

journal_title：Carcinogenesis

authors： Jones DE Jr,Evces S,Lindahl R

更新日期：1984-12-01 00:00:00

abstract：:Primary hepatocyte cultures from six human donors were established and their abilities to metabolize the polycyclic aromatic hydrocarbon carcinogen benzo[a]pyrene (B[a]P) were examined. Cells from each donor were plated at similar densities (1 X 10(7) cells/100 mm dish). All cultures metabolized B[a]P to a significant...

journal_title：Carcinogenesis

authors： Moore CJ,Gould MN

更新日期：1984-12-01 00:00:00

abstract：:The organochlorine pesticides chlordane and heptachlor were demonstrated to be liver neoplasm promoters in mice. Male B6C3F1 mice exposed to diethylnitrosamine (DEN) for 14 weeks followed by 25 weeks on control diet developed a 40% incidence of liver neoplasms whereas those given chlordane or heptachlor afterwards had...

journal_title：Carcinogenesis

authors： Williams GM,Numoto S

更新日期：1984-12-01 00:00:00

abstract：:A methodology for the isolation and culture of rat nasal turbinates was developed with the aim of studying chemically-induced genotoxic effects in the nasal epithelium. DNA damage, as assessed by alkaline elution, and unscheduled DNA synthesis, as measured by quantitative autoradiography, were observed in the cells of...

journal_title：Carcinogenesis

authors： Bermudez E,Allen PF

更新日期：1984-11-01 00:00:00

abstract：:We compared the frequencies of mutation and morphological transformation in relation to the repair of potentially lethal damage (PLD) and sublethal damage (SLD) in X-irradiated golden hamster embryo (GHE) cells. The repair of PLD induced in GHE cells by X-rays was shown to be an error-free process which reduced the fr...

journal_title：Carcinogenesis

authors： Watanabe M,Suzuki N,Sawada S,Nikaido O

更新日期：1984-10-01 00:00:00

abstract：:Botryodiplodin induces DNA-protein cross-links (DPC) in mammalian cells in culture. Removal of the mycotoxin followed by incubation of cells in fresh medium leads to the gradual disappearance of DPC. The present experiments attempted to determine to what extent the repair mechanism acts through a system involving tran...

journal_title：Carcinogenesis

authors： Moulé Y,Darracq N

更新日期：1984-10-01 00:00:00

abstract：:Forty-two compounds belonging to various chemical groups have been tested for their ability to suppress formation of aflatoxin B1--DNA adduct mediated by microsome in vitro. While many of these compounds have either marginal or no modulating effect, some have been identified as effective inhibitors. The strong inhibit...

journal_title：Carcinogenesis

authors： Bhattacharya RK,Firozi PF,Aboobaker VS

更新日期：1984-10-01 00:00:00

abstract：:Liver microsomes from male Syrian golden hamsters and Sprague Dawley rats metabolize the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine (NNDM) to N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) as the major product detectable by h.p.l.c. The rates of total metabolism are similar for both the cis and tr...

journal_title：Carcinogenesis

authors： Kokkinakis D,Hollenberg PF,Scarpelli DG

更新日期：1984-08-01 00:00:00

abstract：:The complete tumour promoter phorbol, 12-myristate, 13-acetate (PMA) induces terminal differentiation in the majority of normal cultured human and mouse keratinocytes but a subpopulation exists which is resistant to this effect (PMAR). We have compared with PMA the effects of mezerein (Mez) and phorbol, 12-retinoate, ...

journal_title：Carcinogenesis

authors： Parkinson EK,Pera MF,Emmerson A,Gorman PA

更新日期：1984-08-01 00:00:00

abstract：:In efforts to determine common and consistent morphological parameters of transformation in C3H/10T1/2 cells, 15 cell lines transformed by different carcinogens were examined with the scanning electron microscope (SEM) and compared to non-transformed cells. Cell lines were studied at different passages, at different c...

journal_title：Carcinogenesis

authors： Narayan KS,Young R,Heidelberger C,Landolph JR

更新日期：1984-07-01 00:00:00

abstract：:The relationship between striatal dopamine-stimulated adenylate cyclase (DAC) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors was studied. An inverse correlation between activity of this enzyme and the number and growth of tumors was observed in several strains and substrains of rats. Chronic, but not...

journal_title：Carcinogenesis

authors： Goldman PR,Vogel WH

更新日期：1984-07-01 00:00:00

abstract：:Several nitroarenes derived from benzo[a]pyrene and perylene and the parent hydrocarbons have been assayed for mutagenicity in the Salmonella microsome test and for affinity for the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-receptor protein in rat liver cytosol. 1- and 3-nitrobenzo[a]pyrene are mutagenic in the absen...

journal_title：Carcinogenesis

authors： Löfroth G,Toftgård R,Nilsson L,Agurell E,Gustafsson JA

更新日期：1984-07-01 00:00:00

abstract：:For a group of nine hydrocarbon and halogenated hydrocarbon epoxides, there is shown to be a good correlation between their abilities to inhibit epoxide hydrase and the quantity Vmin /Es, where Vmin is the most negative value of the molecule's electrostatic potential in the neighborhood of the epoxide oxygen and Es is...

journal_title：Carcinogenesis

authors： Politzer P,Laurence PR

更新日期：1984-06-01 00:00:00